AustralieFrV1, Main, Exploration, bibRecord, 003B10

Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI

Identifieur interne : 003B10 ( Main/Exploration ); précédent : 003B09; suivant : 003B11

Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI

Auteurs : Edward A. Copelan [États-Unis] ; Belinda Avalos [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Xiaochun Zhu [États-Unis] ; Robert Peter Gale [Royaume-Uni] ; Michael R. Grunwald [États-Unis] ; Mehdi Hamadani [États-Unis] ; Betty K. Hamilton [États-Unis] ; Gregory A. Hale [États-Unis] ; David I. Marks [Royaume-Uni] ; Edmund K. Waller [États-Unis] ; Bipin N. Savani [États-Unis] ; Luciano J. Costa [États-Unis] ; Muthalagu Ramanathan [États-Unis] ; Jean-Yves Cahn [France] ; H. Jean Khoury [États-Unis] ; Daniel J. Weisdorf [États-Unis] ; Yoshihiro Inamoto [États-Unis] ; Rammurti T. Kamble [États-Unis] ; Harry C. Schouten [Pays-Bas] ; Baldeep Wirk [États-Unis] ; Mark R. Litzow [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Koen W. Van Besien [États-Unis] ; Celalettin Ustun [États-Unis] ; Brian J. Bolwell [États-Unis] ; Christopher N. Bredeson [Canada] ; Omotayo Fasan [États-Unis] ; Nilanjan Ghosh [États-Unis] ; Mary M. Horowitz [États-Unis] ; Mukta Arora [États-Unis] ; Jeffrey Szer [Australie] ; Alison W. Loren [États-Unis] ; Edwin P. Alyea [États-Unis] ; Jorge Cortes [États-Unis] ; Richard T. Maziarz [États-Unis] ; Matt E. Kalaycio [États-Unis] ; Wael Saber [États-Unis]

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2014.

RBID : PMC:4329042

Descripteurs français

English descriptors

KwdEn :
- Administration, Intravenous, Administration, Oral, Adolescent, Adult, Allografts, Busulfan (administration & dosage), Cyclophosphamide (administration & dosage), Disease-Free Survival, Female, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive (mortality), Leukemia, Myelogenous, Chronic, BCR-ABL Positive (therapy), Male, Middle Aged, Myeloablative Agonists (administration & dosage), Siblings, Survival Rate, Transplantation Conditioning, Whole-Body Irradiation.
MESH :
- chemical , administration & dosage : Busulfan, Cyclophosphamide, Myeloablative Agonists.
- mortality : Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
- therapy : Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
- Administration, Intravenous, Administration, Oral, Adolescent, Adult, Allografts, Disease-Free Survival, Female, Humans, Male, Middle Aged, Siblings, Survival Rate, Transplantation Conditioning, Whole-Body Irradiation.

Abstract

Cyclophosphamide in combination with busulfan (Bu) or total body irradiation (TBI) are the most commonly used myeloablative conditioning regimens in patients with Chronic Myeloid Leukemia (CML). We used data from the Center for International Bone Marrow Transplantation Research to compare outcomes in adults who underwent hematopoietic cell transplantation for CML in first chronic phase following myeloablative conditioning with cyclophosphamide (Cy) in combination with TBI, oral Bu or intravenous (IV) Bu. Four hundred thirty-eight adults received human leukocyte antigen (HLA)-matched sibling grafts and 235 received well-matched grafts from unrelated donors from 2000 through 2006. Important differences existed between the groups in distribution of donor relation, exposure to tyrosine kinase inhibitors and year of transplantation. In multivariate analysis, relapse occurred less frequently among patients receiving IV Bu compared to TBI (RR=0.36; P=0.022) or oral Bu (RR=0.39; P=0.028), but non-relapse mortality and survival were similar. A significant interaction was detected between donor relation and the main effect in leukemia-free survival (LFS). Among recipients of HLA-identical sibling grafts, but not URD grafts, LFS was better in patients receiving IV (RR=0.53; P=0.025) or oral Bu (RR=0.64; P=0.017) compared to TBI. In CML in first chronic phase, Cy in combination with IV Bu was associated with less relapse than TBI or oral Bu. LFS was better following IV or oral Bu compared to TBI.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329042

DOI: 10.1016/j.bbmt.2014.12.010
PubMed: 25528388
PubMed Central: 4329042

Affiliations:

Le document en format XML

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<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
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<author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R." last="Grunwald">Michael R. Grunwald</name>
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<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
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<author><name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name>
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<author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
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<placeName><region type="state">Floride</region>
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<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
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<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
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<wicri:cityArea>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
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<placeName><region type="state">Tennessee</region>
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<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
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<placeName><region type="state">Caroline du Sud</region>
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<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston</wicri:cityArea>
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</author>
<author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name>
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<placeName><region type="state">Massachusetts</region>
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<wicri:cityArea>UMass Memorial Medical Center, Worcester</wicri:cityArea>
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</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Hematology, University Hospital, Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
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</author>
<author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
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<placeName><region type="state">Minnesota</region>
</placeName>
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<author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
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<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
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<author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
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</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Medical Oncology, Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Medical Oncology, Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Hematology and Oncology, Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name>
<affiliation wicri:level="1"><nlm:aff id="A21">The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fasan, Omotayo" sort="Fasan, Omotayo" uniqKey="Fasan O" first="Omotayo" last="Fasan">Omotayo Fasan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Alyea, Edwin P" sort="Alyea, Edwin P" uniqKey="Alyea E" first="Edwin P." last="Alyea">Edwin P. Alyea</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Hematology and Oncology, Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI</title>
<author><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Avalos, Belinda" sort="Avalos, Belinda" uniqKey="Avalos B" first="Belinda" last="Avalos">Belinda Avalos</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College of London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College of London</wicri:regionArea>
<wicri:noRegion>Imperial College of London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R." last="Grunwald">Michael R. Grunwald</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Hematology and Oncology, Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Hematology/Oncology, All Children’s Hospital, St. Petersburg, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, All Children’s Hospital, St. Petersburg</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:aff id="A7">University Hospitals Bristol NHS Trust, Bristol, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Hospitals Bristol NHS Trust, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Sud</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name>
<affiliation wicri:level="2"><nlm:aff id="A11">UMass Memorial Medical Center, Worcester, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>UMass Memorial Medical Center, Worcester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Hematology, University Hospital, Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Division of Hematology and Oncology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Divison of Hematology, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A20">Department of Medical Oncology, Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Medical Oncology, Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Hematology and Oncology, Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name>
<affiliation wicri:level="1"><nlm:aff id="A21">The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Ottawa Hospital Blood & Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fasan, Omotayo" sort="Fasan, Omotayo" uniqKey="Fasan O" first="Omotayo" last="Fasan">Omotayo Fasan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Levine Cancer Institute, Carolinas Healthcare System, Charlotte, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Alyea, Edwin P" sort="Alyea, Edwin P" uniqKey="Alyea E" first="Edwin P." last="Alyea">Edwin P. Alyea</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Hematology and Oncology, Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intravenous</term>
<term>Administration, Oral</term>
<term>Adolescent</term>
<term>Adult</term>
<term>Allografts</term>
<term>Busulfan (administration & dosage)</term>
<term>Cyclophosphamide (administration & dosage)</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Humans</term>
<term>Leukemia, Myelogenous, Chronic, BCR-ABL Positive (mortality)</term>
<term>Leukemia, Myelogenous, Chronic, BCR-ABL Positive (therapy)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Myeloablative Agonists (administration & dosage)</term>
<term>Siblings</term>
<term>Survival Rate</term>
<term>Transplantation Conditioning</term>
<term>Whole-Body Irradiation</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie intraveineuse</term>
<term>Administration par voie orale</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Agonistes myélo-ablatifs (administration et posologie)</term>
<term>Allogreffes</term>
<term>Busulfan (administration et posologie)</term>
<term>Conditionnement pour greffe</term>
<term>Cyclophosphamide (administration et posologie)</term>
<term>Femelle</term>
<term>Fratrie</term>
<term>Humains</term>
<term>Irradiation corporelle totale</term>
<term>Leucémie myéloïde chronique BCR-ABL positive ()</term>
<term>Leucémie myéloïde chronique BCR-ABL positive (mortalité)</term>
<term>Mâle</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Busulfan</term>
<term>Cyclophosphamide</term>
<term>Myeloablative Agonists</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Agonistes myélo-ablatifs</term>
<term>Busulfan</term>
<term>Cyclophosphamide</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Leukemia, Myelogenous, Chronic, BCR-ABL Positive</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Leucémie myéloïde chronique BCR-ABL positive</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Leukemia, Myelogenous, Chronic, BCR-ABL Positive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Intravenous</term>
<term>Administration, Oral</term>
<term>Adolescent</term>
<term>Adult</term>
<term>Allografts</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Siblings</term>
<term>Survival Rate</term>
<term>Transplantation Conditioning</term>
<term>Whole-Body Irradiation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie intraveineuse</term>
<term>Administration par voie orale</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Allogreffes</term>
<term>Conditionnement pour greffe</term>
<term>Femelle</term>
<term>Fratrie</term>
<term>Humains</term>
<term>Irradiation corporelle totale</term>
<term>Leucémie myéloïde chronique BCR-ABL positive</term>
<term>Mâle</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Cyclophosphamide in combination with busulfan (Bu) or total body irradiation (TBI) are the most commonly used myeloablative conditioning regimens in patients with Chronic Myeloid Leukemia (CML). We used data from the Center for International Bone Marrow Transplantation Research to compare outcomes in adults who underwent hematopoietic cell transplantation for CML in first chronic phase following myeloablative conditioning with cyclophosphamide (Cy) in combination with TBI, oral Bu or intravenous (IV) Bu. Four hundred thirty-eight adults received human leukocyte antigen (HLA)-matched sibling grafts and 235 received well-matched grafts from unrelated donors from 2000 through 2006. Important differences existed between the groups in distribution of donor relation, exposure to tyrosine kinase inhibitors and year of transplantation. In multivariate analysis, relapse occurred less frequently among patients receiving IV Bu compared to TBI (RR=0.36; P=0.022) or oral Bu (RR=0.39; P=0.028), but non-relapse mortality and survival were similar. A significant interaction was detected between donor relation and the main effect in leukemia-free survival (LFS). Among recipients of HLA-identical sibling grafts, but not URD grafts, LFS was better in patients receiving IV (RR=0.53; P=0.025) or oral Bu (RR=0.64; P=0.017) compared to TBI. In CML in first chronic phase, Cy in combination with IV Bu was associated with less relapse than TBI or oral Bu. LFS was better following IV or oral Bu compared to TBI.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
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<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
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<li>Massachusetts</li>
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<li>Ohio</li>
<li>Oregon</li>
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<li>Rhône-Alpes</li>
<li>Tennessee</li>
<li>Texas</li>
<li>Washington (État)</li>
<li>Wisconsin</li>
<li>État de New York</li>
</region>
<settlement><li>Grenoble</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Copelan, Edward A" sort="Copelan, Edward A" uniqKey="Copelan E" first="Edward A." last="Copelan">Edward A. Copelan</name>
</region>
<name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<name sortKey="Alyea, Edwin P" sort="Alyea, Edwin P" uniqKey="Alyea E" first="Edwin P." last="Alyea">Edwin P. Alyea</name>
<name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<name sortKey="Avalos, Belinda" sort="Avalos, Belinda" uniqKey="Avalos B" first="Belinda" last="Avalos">Belinda Avalos</name>
<name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name>
<name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<name sortKey="Fasan, Omotayo" sort="Fasan, Omotayo" uniqKey="Fasan O" first="Omotayo" last="Fasan">Omotayo Fasan</name>
<name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name>
<name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R." last="Grunwald">Michael R. Grunwald</name>
<name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<name sortKey="Hamilton, Betty K" sort="Hamilton, Betty K" uniqKey="Hamilton B" first="Betty K." last="Hamilton">Betty K. Hamilton</name>
<name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
<name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
<name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name>
<name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name>
<name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name>
<name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name>
<name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
</noRegion>
<name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name>
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<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<country name="Pays-Bas"><noRegion><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
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<country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
</noRegion>
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<country name="Canada"><noRegion><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name>
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<country name="Australie"><noRegion><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI

Comparison of Outcomes of Allogeneic Transplantation for CML with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan or TBI

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